How Does CBD Interact with Your Immune System?

*This article is purely informational and does not constitute medical advice. Consult your healthcare provider about CBD.

CBD immune system
CBD immune system

CBD Immune System

CBD immune system claims: is there any merit to them?

The immune system is a vital component to keep your body healthy and functioning. For one, the immune system takes charge of eliminating foreign bodies like viruses. But on the other hand, a malfunctioning immune system can also harm your body – multiple sclerosis and systemic lupus are examples of this.

CBD and the Immune System

CBD the cannabinoid

CBD is a cannabinoid commonly found in cannabis or hemp plants. It is one of the primary active compounds found in cannabis plants, alongside its sibling – delta-9-tetrahydrocannabinol (THC).

Contrary to popular belief, CBD is nonintoxicating and will not give you a high. That notion is actually due to the effects of THC.

The Endocannabinoid System

The endocannabinoid system (ECS) is a network spanning multiple organ systems in the human body. These systems will include the muscular, cardiac, neural, and even the immune system.

Because of such a massive area covered by the ECS, scientists explain that the ECS becomes responsible for regulating many different body functions.

How does CBD interact with the Immune System?

One of the effects of the interaction between CBD and the ECS is called immunomodulation.

But how does CBD immune system interaction specifically work? In general, cannabinoids (like CBD) and endocannabinoids communicate by binding or attaching to CB1 or CB2 receptors.

These receptors are found in various places in the body such as the brain, muscles, heart, and more. This results in what was earlier mentioned as the wide-reaching regulatory effects of the ECS on the body. 

Specifically, CBD immune system interactions stem from activating the ECS and result in immunomodulatory effects.

Weak Immune System Equals Weak Body

Causes of a Weak Body

A primary reason for getting sick is due to having a body in a weakened state. Just like castle walls, poor maintenance and a lack of support can lead to intruders slipping through the cracks.

Weakened bodies are more susceptible to viruses, inflammations, coughs, colds, and more.

Lack of sleep and unnecessary amounts of stress are key contributors that make and keep the body in a weakened state. 

According to the Center for Disease Control, 1 in 3 Americans doesn’t get enough sleep. Meanwhile, the American Institute of Stress reports that 33% of people feel extreme stress with 48% of people having trouble sleeping because of stress.

Generally speaking, a well-maintained body does not need much external help or boosts. But it helps to have a back-up, more so in situations where the body is in a weakened state.


Inflammation, believe it or not, is an immune response of the body. Different organs such as the muscles, eye corneas, and so on get inflamed when damage occurs.

For example, muscles become inflamed as it accrues damage from exertion when working out. This is because the immune system activates a variety of cells like neutrophils, macrophages, and satellite cells. The system sends them to the areas of damage.

How does CBD play into this? CBD interacts either via the ECS or directly to the cells involved

There are various pathways involved that are beyond the scope of this article.

Immunosuppressant versus Autoimmunity

Multiple sclerosis (MS) is a slow yet fatal disease where the immune system attacks the nervous system. The immune system causes MS by destroying the myelin sheath of the nervous system which is a protective cover for nerves.

But why would the immune system do this? Autoimmune diseases are situations in the body where the immune system is overactive and cannot differentiate its own cells from harmful invaders. Because of this, the body is slowly being damaged and eroded by its own defense mechanism which leads to different diseases like MS and rheumatoid arthritis.

Bottom Line and Wrap

As previously mentioned, the immune system is so holistically involved in maintaining body wellness that affectations of this can cause impactful upswings and downswings. Therefore, treatment avenues that go through the immune system are vital as it is a direct route to both simple and complicated diseases that affect the body.

As it stands, over-the-counter remedies and therapeutic solutions have yet to cover every immune disease known to man. In fact, many autoimmune diseases like MS still have no cure and can only be managed as it progresses in the body.

But whether or not CBD may have a vital role to play in your life, please remember to seek the advice of a medical professional first.  


The studies presented do not imply that CBD can treat the condition mentioned. Moreover, the information presented here is not meant as a substitute or alternative to information from healthcare professionals. Consult your healthcare provider about CBD before use.

“These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”

Categories cannabinoids

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