CBD Drug Interactions – Will this Affect Me?

*This article is purely informational and does not constitute medical advice. Consult your healthcare provider about CBD.

CBD drug interactions

CBD Drug Interactions

CBD Drug Interactions – Will this Affect Me? Yes, in particular cases (or medications). Let’s find out.

CBD consumer sales are expected to hit around $1.8 billion by 2022. However, it is not just the sales figures that tell the story of increased CBD use. 

Another set of analytics has shown that 20% of people ages 18 – 29 already use CBD consistently, while 40% of the same age group have tried it at least once.

But the rampant use of CBD doesn’t necessarily spell “worry-free.” While the World Health Organization (WHO) says “CBD has a good safety profile,” they also warn about its adverse effects.

The WHO states explicitly that the problems can lie with CBD drug interactions.

What is CBD?

CBD or cannabidiol is a phytocannabinoid naturally present in the cannabis plant family. In the United States, CBD is typically extracted from the hemp plant. That is because of the 2018 Farm Bill that allows hemp and hemp-related products to be produced so long as it follows strict regulations.

RELATED: 2018 Farm Bill CBD: How Does the Bill Relate to CBD?

CBD in its most common consumer form is CBD oil, where CBD extract is mixed with a carrier oil such as MCT oil, olive oil, and avocado oil. 

As of late, Epidiolex is the first legal drug with CBD as the primary ingredient. Here, CBD is used primarily to treat Lennox-Gastaut syndrome and Dravet syndrome, two rare but severe forms of epilepsy.

Most people associate cannabis-related products with intoxication or high. But that is primarily due to THC or tetrahydrocannabinol. On the other hand, CBD cannot cause such intoxicating effects. 

Does CBD Interfere with Other Medications?

Yes. Going back to the earlier statement of the WHO, many of CBD’s adverse effects can come from CBD drug interactions.

Medications follow different pathways as they work inside the human body. For example, medicines are broken down into enzymes and such. CBD can interfere with the said interactions. 

In one study, 57 medications are considered dangerous when administered in the presence of CBD. Many of these drugs are heart medications or antibiotics.

Is CBD Safe to Use with Other Medications?

Yes and no. As mentioned earlier, different medications have different working modes inside the human body. Likewise, there may also be pre-existing health conditions a user may have that can affect how drugs and CBD can interact.

A key takeaway is to always consult your healthcare provider before using CBD. Their professional input plays a vital role in determining if CBD can help you or become a detriment to you.

CBD Toxicity

CBD has considerations for being safe for use; however, excessive intake is not recommended. The FDA has warned the public about CBD’s potential harm and side effects.

Excessive consumption of CBD can have the following side-effects, but are not limited to:

–   Vomiting

–   Diarrhea

–   Drowsiness

–   Fatigue

–   Appetite Loss

CBD must also be avoided if medications have a grapefruit warning on their label.

According to the FDA, grapefruits can cause increases in the concentration of medication in the bloodstream. This interaction may cause adverse side effects or, potentially, an overdose. Research suggests that CBD may have a similar interaction to grapefruit.

In another vein, research submitted to the FDA suggests that CBD does not cause liver toxicity. Investigators of the study conducted the trial on 839 adults taking oral CBD.

CBD Drug Interaction List

Here is a list of various medications and how CBD may interfere with their functions.

–  CBD oil and blood pressure medication

o   CBD and Statins

Statins contain an enzyme called CYP3A4. This enzyme is responsible for metabolizing almost half of the drugs sold commercially. 

CYP3A4 loses its effectiveness when taken with CBD, known as its potent inhibitor.

o   CBD oil and Beta-blockers

Beta-blockers are responsible for lowering heart rate by inhibiting the effects of epinephrine – or more commonly known as adrenaline. 

Consumption of CBD with beta-blockers may enhance the effects of beta-blockers on the body, some of which include:

§  Lethargy

§  Dizziness

§  Weakness

§  Shock

§  Fainting

–  CBD oil and antidepressants

o   CBD oil and SSRI interaction

A common component of antidepressants is Selective Serotonin Reuptake Indicators or SSRIs. 

SSRIs function by increasing serotonin levels in the brain by preventing their reabsorption. In doing so, SSRI eases moderate to severe depression symptoms with relatively fewer side effects.

However, consuming CBD with SSRIs increases their concentrations on the body. That means that CBD can enhance the side-effects of SSRIs or, worse, remove the therapeutic effects of SSRIs altogether.

o   CBD oil and Zoloft interaction

Zoloft is a brand name for Sertraline, an antidepressant. Sertraline is also an SSRI that increases serotonin in the brain. It is also used to treat bipolar disorder and depressive episodes. 

Like the previous section, CBD can enhance SSRIs’ side effects on the body. Worse still, CBD can negate the therapeutic effects of SSRIs.

o   CBD oil and Cymbalta

Cymbalta is used to treat anxiety disorder, major depressive disorder, fibromyalgia, diabetic neuropathy, and muscle pain.

Similar to Sertraline, CBD oil and Cymbalta should not be taken together. This is because CBD can increase the side effects of Cymbalta or remove its effectiveness altogether.

–  CBD and Adderall Interaction

Adderall, a stimulant, is considered a treatment for people with Attention Deficit Hyperactivity Disorder or ADHD. It also helps people with narcolepsy stay awake while also helping reduce impulsive behavior.

Like the drugs mentioned earlier, consuming CBD and Adderall together may lead to a loss of appetite. Likewise, CBD may also inhibit the effects of Adderall on the person.

–  CBD and Levothyroxine

Levothyroxine is a thyroid medication that replaces the hormones produced by the thyroid gland.

RELATED: Does CBD Affect Hormones?: CBD Hit Differently on Women and Men

It is believed that taking CBD and Levothyroxine can increase the amount of thyroxine accumulated in the body, leading to hyperthyroidism.

–  CBD Oil and Antihistamines

Antihistamines are over-the-counter medications used to treat symptoms of allergies. Using CBD oil with antihistamines may increase the severity of side effects such as insomnia, vomiting, diarrhea, etc.

The Wrap on CBD Drug Interactions

Will CBD drug interactions affect me? Yes.

While CBD is known to have a good safety profile, research suggests that CBD also interferes or inhibits the effects of different medications. At the same time, CBD has its fair share of side-effects that must also be considered.

The takeaway from this is to consult with your doctor before using CBD. Their opinion will help complete your understanding of your health and body.

“These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”

Categories CBD Beginners

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